Npm3 Gene Summary [Mouse]

Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Acts upstream of or within rRNA processing and rRNA transcription. Located in nucleolus. Is expressed in several structures, including alimentary system; endocrine gland; male reproductive gland or organ; ovary follicle; and respiratory system. Orthologous to human NPM3 (nucleophosmin/nucleoplasmin 3). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Npm3
Official Name
nucleoplasmin 3 [Source:MGI Symbol;Acc:MGI:894653]
Ensembl ID
ENSMUSG00000056209
Bio databases IDs NCBI: 18150 Ensembl: ENSMUSG00000056209
Aliases nucleoplasmin 3
Synonyms Nub1, nucleophosmin/nucleoplasmin 3, nucleophosmin/nucleoplasmin, 3, nucleoplasmin 3, PORMIN, RGD1565542, TMEM123
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Npm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Nucleoplasmin-like domain
  • protein binding

Pathways

Biological processes and signaling networks where the Npm3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • metastasis
  • prostatic neoplasm
  • prostatic neoplasia
regulated by
role in cell
  • growth
  • invasion by
  • processing in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • actin cytoskeleton
  • cytosol
  • nucleoli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Npm3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • chromatin remodeling
  • rRNA transcription
  • rRNA processing

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • actin cytoskeleton
  • cytosol
  • nucleolus
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding
  • histone binding
  • chromatin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.