TRIP13 Gene Summary [Human]
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | TRIP13 |
| Official Name | thyroid hormone receptor interactor 13 [Source:HGNC Symbol;Acc:HGNC:12307] |
| Ensembl ID | ENSG00000071539 |
| Bio databases IDs | |
| Aliases | thyroid hormone receptor interactor 13, thyroid receptor interacting protein 13 |
| Synonyms | 16E1BP, 2410002G23Rik, D13Ertd328e, MVA3, OOMD9, OZEMA9, thyroid hormone receptor interactor 13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIP13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA domain (dynein-related subfamily)
- transcription regulator
- ATPase family associated with various cellular activities (AAA)
- AAA ATPase domain
- transcription cofactor
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- mosaic variegated aneuploidy syndrome type 3
- organismal death
- colorectal cancer
- colon carcinoma
- oocyte/zygote/embryo maturation arrest 9
- HER2 negative hormone receptor negative breast cancer
role in cell
- S phase
- expression in
- apoptosis
- quantity
- proliferation
- formation
- formation in
- mitotic catastrophe
- accumulation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIP13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- reciprocal meiotic recombination
- spermatid development
- spermatogenesis
- synaptonemal complex assembly
- male meiosis I
- transcription from RNA polymerase II promoter
- female meiosis I
- double-strand break repair
- meiotic recombination checkpoint
- oocyte maturation
- oogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- transcription cofactor activity
- protein binding