PIGL Gene Summary [Human]
This gene encodes an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | PIGL |
| Official Name | phosphatidylinositol glycan anchor biosynthesis class L [Source:HGNC Symbol;Acc:HGNC:8966] |
| Ensembl ID | ENSG00000108474 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol glycan anchor biosynthesis class L, N-acetylglucosaminylphosphatidylinositol deacetylase |
| Synonyms | CHIME, Gm737, LOC102724483, phosphatidylinositol glycan anchor biosynthesis class L, phosphatidylinositol glycan anchor biosynthesis, class L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIGL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetylglucosaminylphosphatidylinositol deacetylase
- GlcNAc-PI de-N-acetylase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- mitochondria-associated membranes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIGL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GPI anchor biosynthetic process
- preassembly of GPI anchor in ER membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- N-acetylglucosaminylphosphatidylinositol deacetylase activity