RAMP3 Gene Summary [Human]
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RAMP3 |
| Official Name | receptor activity modifying protein 3 [Source:HGNC Symbol;Acc:HGNC:9845] |
| Ensembl ID | ENSG00000122679 |
| Bio databases IDs | |
| Aliases | receptor activity modifying protein 3 |
| Synonyms | receptor activity modifying protein 3, receptor (calcitonin) activity modifying protein 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAMP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- adrenomedullin receptor
- Receptor activity modifying family
- tail domain
- protein binding
- PDZ binding motif
- coreceptor
Pathways
Biological processes and signaling networks where the RAMP3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- hypoglycemia
- insulin-dependent diabetes mellitus
- impaired glucose tolerance
- neoplasia
- metastasis
- colon cancer
- lung adenocarcinoma
role in cell
- expression in
- cell death
- phosphorylation in
- activation in
- migration
- production in
- morphology
- binding
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Nucleus
- vesicles
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAMP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- protein transport
- cross-receptor inhibition within G-protein coupled receptor heterodimer
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- intracellular protein transport
- positive regulation of calcium-mediated signaling
- positive regulation of protein kinase A signaling cascade
- cellular response to estradiol stimulus
- positive regulation of receptor recycling
- positive regulation of gene expression
- calcium ion transport
- positive regulation of ERK1 and ERK2 cascade
- cellular response to hormone stimulus
- receptor internalization
- positive regulation of protein kinase B signaling cascade
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
- cell surface
- lysosome
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding
- adrenomedullin receptor activity
- beta-amyloid binding