LRRC59 Gene Summary [Human]
Enables RNA binding activity and cadherin binding activity. Predicted to be involved in positive regulation of Ras protein signal transduction and signal transduction. Located in endoplasmic reticulum and mitochondrial nucleoid. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LRRC59 |
| Official Name | leucine rich repeat containing 59 [Source:HGNC Symbol;Acc:HGNC:28817] |
| Ensembl ID | ENSG00000108829 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 59 |
| Synonyms | AA959742, leucine rich repeat containing 59, p34, PRO1855 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LRRC59 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine rich repeat
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- urothelial bladder carcinoma
- transitional cell bladder cancer
- bladder cancer
- HER2 negative hormone receptor negative breast cancer
role in cell
- expression in
- migration
- proliferation
- invasion by
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- Endoplasmic Reticulum
- mitochondrial nucleoids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LRRC59 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- cytoplasm
- membrane
- endoplasmic reticulum
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- RNA binding
- protein binding
- cadherin binding