NEIL3 Gene Summary [Human]
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | NEIL3 |
| Official Name | nei like DNA glycosylase 3 [Source:HGNC Symbol;Acc:HGNC:24573] |
| Ensembl ID | ENSG00000109674 |
| Bio databases IDs | |
| Aliases | nei like DNA glycosylase 3, zinc finger, GRF-type containing 3 |
| Synonyms | BC034753, C85903, FGP2, FLJ10858, FPG2, hFPG2, hNEI3, NEI3, nei like 3 (E. coli), nei-like DNA glycosylase 3, RGD1310562, ZGRF3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEIL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA N-glycosylase
- DNA secondary structure binding
- DNA-(apurinic or apyrimidinic site) lyase
- GRF zinc finger
- enzyme
- Fpg/Nei N-terminal protein domain
- Zn-finger in Ran binding protein and others
- binding protein
- damaged DNA binding
- single-stranded DNA binding
- double-stranded DNA binding
- zinc finger domain
- Formamidopyrimidine-DNA glycosylase H2TH domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- tumorigenesis
- neurological disorder
- silicosis
- glioblastoma
- glioblastoma cancer
role in cell
- proliferation
- expression in
- migration
- number
- differentiation
- neurogenesis
- quantity
- invasion by
- repair in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEIL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- base-excision repair
- base-excision repair, AP site formation
- depurination
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- double-stranded DNA binding
- bubble DNA binding
- DNA N-glycosylase activity
- DNA-(apurinic or apyrimidinic site) lyase activity
- damaged DNA binding
- single-stranded DNA binding