HNRNPDL Gene Summary [Human]
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011]
Details
| Type | Protein Coding |
| Official Symbol | HNRNPDL |
| Official Name | heterogeneous nuclear ribonucleoprotein D like [Source:HGNC Symbol;Acc:HGNC:5037] |
| Ensembl ID | ENSG00000152795 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein D like |
| Synonyms | D5Ertd650e, D5Wsu145e, heterogeneous nuclear ribonucleoprotein D-like, HNRDL, HNRNP, Hnrnpdl1, HNRNP-D LIKE, HNRPDL, JKTBP, JKTBP1, JKTBP2, laAUF1, LGMD1G, LGMDD3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HNRNPDL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- HuR Nucleocytoplasmic Shuttling domain
- single-stranded DNA binding
- double-stranded DNA binding
- RNA recognition motif
- nuclear localization sequence
- poly(A) binding protein
- protein binding
- glycine tyrosine rich domain
- single-stranded RNA binding
- DNA binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- Alzheimer disease
- limb-girdle muscular dystrophy type 1G
- Parkinson disease
- autosomal dominant limb-girdle muscular dystrophy
- Huntington disease
- infection by HIV-1
role in cell
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- synapse
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HNRNPDL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of gene expression
Cellular Component
Where in the cell the gene product is active
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- poly(G) RNA binding
- poly(A) RNA binding