YBX3 Gene Summary [Human]
Enables RNA binding activity. Involved in cellular hyperosmotic response; cellular response to tumor necrosis factor; and negative regulation of programmed cell death. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | YBX3 |
| Official Name | Y-box binding protein 3 [Source:HGNC Symbol;Acc:HGNC:2428] |
| Ensembl ID | ENSG00000060138 |
| Bio databases IDs | |
| Aliases | Y-box binding protein 3, cold-shock domain containing A1 |
| Synonyms | COLD SHOCK domain protein A, CSDA, CSDA1, DBPA, DNA-binding protein A, Dpba, MSY3, MSY4, oxyR, RYB-alpha Y box-binding, RYB-α Y box-binding, Yb2, Y-box binding protein 3, Y box protein 3, ZONAB |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YBX3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S1_like
- transcription regulator
- nucleic acid binding
- enzyme binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- Cold shock protein domain
- RNA binding
- mRNA 3' UTR binding
- single-stranded DNA binding
- double-stranded DNA binding
- ribonucleoprotein binding
Pathways
Biological processes and signaling networks where the YBX3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- organismal death
- exencephaly
- Rett syndrome
- cholangiocarcinoma
- cholangiocarcinoma cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- expression in
- apoptosis
- proliferation
- differentiation
- cellular infiltration by
- response by
- fertilization
- density
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- polyribosome fractions
- Cytoplasm
- perinuclear region
- cytosol
- synapse
- gap junctions
- tight junctions
- stress granule
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YBX3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-UTR-mediated mRNA stabilization
- germ cell programmed cell death
- male gonad development
- spermatogenesis
- positive regulation of organ growth
- fertilization
- negative regulation of necroptosis
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of cytoplasmic translation
- in utero embryonic development
- negative regulation of skeletal muscle tissue development
- cellular hyperosmotic response
- apoptotic process
- regulation of gene expression
- cellular response to tumor necrosis factor
- negative regulation of reproductive process
Cellular Component
Where in the cell the gene product is active
- nucleus
- tight junction
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- synapse
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- RNA binding
- protein binding
- ribonucleoprotein complex binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- small GTPase binding
- mRNA 3'-UTR binding