BTN1A1 Gene Summary [Human]
Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BTN1A1 |
| Official Name | butyrophilin subfamily 1 member A1 [Source:HGNC Symbol;Acc:HGNC:1135] |
| Ensembl ID | ENSG00000124557 |
| Bio databases IDs | |
| Aliases | butyrophilin subfamily 1 member A1 |
| Synonyms | BT, BTN, BTN1, butyrophilin subfamily 1 member A1, Butyrophilin, subfamily 1, member a1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BTN1A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- SPRY domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Ig-like V domain
- associated with SPRY domains
- Immunoglobulin V-set domain
- SPRY-associated domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- diabetic nephropathy
role in cell
- proliferation
- metabolism by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- apical cell surfaces
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BTN1A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cytokine production
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- receptor binding