SH3D19 Gene Summary [Human]

This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Details

Type
Processed Transcript
Official Symbol
SH3D19
Official Name
SH3 domain containing 19 [Source:HGNC Symbol;Acc:HGNC:30418]
Ensembl ID
ENSG00000109686
Bio databases IDs NCBI: 152503 Ensembl: ENSG00000109686
Aliases SH3 domain containing 19, EEN binding protein
Synonyms DKFZP434D0215, EBP, EVE-1, Kryn, LOC100361162, RGD1304885, SH3 domain containing 19, SH3 domain protein D19, SH3P19
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SH3D19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • proline-rich binding motif
  • protein binding
  • proline rich domain
  • Src Homology 3 domain superfamily

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • prostatic carcinoma
  • prostate cancer
  • epithelial cancer
  • COVID-19
  • Hutchinson-Gilford progeria syndrome
  • metabolic syndrome X
  • asthma
regulated by
role in cell
  • morphogenesis
  • organization
  • transformation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Cytoplasm
  • cytosol
  • nucleoplasm
  • cell membrane leading edge

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SH3D19 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of cell morphogenesis
  • cytoskeleton organization
  • positive regulation of membrane protein ectodomain proteolysis

Cellular Component

Where in the cell the gene product is active
  • cytosol
  • plasma membrane
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.