TEAD2 Gene Summary [Human]
Enables several functions, including DNA-binding transcription factor activity; disordered domain specific binding activity; and transcription coactivator binding activity. Involved in hippo signaling; positive regulation of transcription, DNA-templated; and protein-containing complex assembly. Located in cytosol and nucleoplasm. Part of TEAD-YAP complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TEAD2 |
| Official Name | TEA domain transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11715] |
| Ensembl ID | ENSG00000074219 |
| Bio databases IDs | |
| Aliases | TEA domain transcription factor 2 |
| Synonyms | Etdf, ETEF-1, ETF, TEA domain family member 2, TEA domain transcription factor 2, TEF-4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TEAD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- YAP binding domain
- transcription factor binding
- protein domain specific binding
- protein binding
- TEA/ATTS domain
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
Pathways
Biological processes and signaling networks where the TEAD2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ventricular septal defect
- exencephaly
- preeclampsia
- chorioallantoic membrane fusion failure
- growth failure
- double outlet right ventricle
role in cell
- expression in
- apoptosis
- proliferation
- differentiation
- response by
- dedifferentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TEAD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- paraxial mesoderm development
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- embryonic organ development
- vasculogenesis
- embryonic heart tube morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- neural tube closure
- notochord development
- lateral mesoderm development
- positive regulation of transcription, DNA-dependent
- cellular response to retinoic acid
- regulation of stem cell differentiation
- hippo signaling cascade
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription coactivator binding