TEAD4 Gene Summary [Human]
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TEAD4 |
| Official Name | TEA domain transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:11717] |
| Ensembl ID | ENSG00000197905 |
| Bio databases IDs | |
| Aliases | TEA domain transcription factor 4, transcriptional enhancer factor 3 |
| Synonyms | EFTR-2, ETFR-2, FR-19, hRTEF-1B, RTEF1, TCF13L1, Tcf13r1, TEA domain family member 4, TEA domain transcription factor 4, TEF-3, Tefr, TEFR-1, Tefr1a |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TEAD4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- DNA binding domain
- nucleic acid binding
- double-stranded DNA binding
- YAP binding domain
- protein binding
- TEA/ATTS domain
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
Pathways
Biological processes and signaling networks where the TEAD4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colon cancer
- organismal death
- colon epithelial cancer
- bladder cancer
- colorectal adenoma
- colorectal adenoma formation
- colon carcinoma
- metastasis
- gastric cancer
role in cell
- expression in
- proliferation
- activation in
- formation
- formation in
- phosphorylation in
- quantity
- migration
- binding in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear envelope
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TEAD4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- trophectodermal cell fate commitment
- skeletal system development
- transcription, DNA-dependent
- hippo signaling cascade
- embryonic organ development
- cell fate specification
- positive regulation of transcription from RNA polymerase II promoter
- embryo implantation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity