HTATIP2 Gene Summary [Human]
Enables protein serine/threonine kinase activity. Involved in import into nucleus and regulation of angiogenesis. Acts upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Located in cytosol and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HTATIP2 |
| Official Name | HIV-1 Tat interactive protein 2 [Source:HGNC Symbol;Acc:HGNC:16637] |
| Ensembl ID | ENSG00000109854 |
| Bio databases IDs | |
| Aliases | HIV-1 Tat interactive protein 2, Tat-interacting protein (30kD), short chain dehydrogenase/reductase family 44U, member 1 |
| Synonyms | CC3, HIV-1 Tat interactive protein 2, HYALURONECTIN, SDR44U1, TAT-INTERACTING protein 30KD, TIP30 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HTATIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- protein serine/threonine kinase
- ATP-binding domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- tumorigenesis
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
role in cell
- growth
- cell viability
- apoptosis
- expression in
- quantity
- signaling in
- cell death
- survival
- phosphorylation in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Mitochondria
- cytosol
- nuclear envelope
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HTATIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- negative regulation of apoptotic process
- apoptotic process
- cell differentiation
- positive regulation of programmed cell death
- protein autophosphorylation
- regulation of angiogenesis
- nuclear import
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- oxidoreductase activity
- protein serine/threonine kinase activity