PTPN5 Gene Summary [Human]
Enables phosphotyrosine residue binding activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be integral component of membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PTPN5 |
| Official Name | protein tyrosine phosphatase non-receptor type 5 [Source:HGNC Symbol;Acc:HGNC:9657] |
| Ensembl ID | ENSG00000110786 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase non-receptor type 5, striatal-enriched protein tyrosine phosphatase |
| Synonyms | FLJ1442, protein tyrosine phosphatase non-receptor type 5, protein tyrosine phosphatase, non-receptor type 5, PTPSTEP, STEP, STEP61 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTPN5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase interacting domain
- protein-tyrosine-phoshatase
- catalytic domain
- Protein tyrosine phosphatase, catalytic domain
- calpain cleavage site
- phosphotyrosine binding
- PTP_DSP_cys
- protein binding
- phosphatase domain
- polyproline motif
- identical protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- phosphatase
Pathways
Biological processes and signaling networks where the PTPN5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic adenocarcinoma
- neurological deficiency
- Alzheimer disease
- pituitary gland adenoma
- adenoma formation
- head and neck neuroendocrine neoplasia
- pancreatic epithelial cancer
- ischemic injury
- Huntington disease
- frontotemporal dementia with tauopathy
role in cell
- apoptosis
- development
- cell death
- phosphorylation in
- survival
- neurotoxicity
- long-term potentiation
- injury
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- synaptic membrane
- nucleoplasm
- synaptic vesicles
- dendrite initial segments
- synaptosomes
- cellular protrusions
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTPN5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- cytosol
- cell junction
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein kinase binding
- protein binding
- protein tyrosine phosphatase activity