TUT1 Gene Summary [Human]
This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009]
Details
| Type | Protein Coding |
| Official Symbol | TUT1 |
| Official Name | terminal uridylyl transferase 1, U6 snRNA-specific [Source:HGNC Symbol;Acc:HGNC:26184] |
| Ensembl ID | ENSG00000149016 |
| Bio databases IDs | |
| Aliases | terminal uridylyl transferase 1, U6 snRNA-specific, RNA uridylyltransferase, U6 TUTase, TUTase 6 |
| Synonyms | 2700038E08Rik, PAPD2, RBM21, STARPAP, TENT1, terminal uridylyl transferase 1, U6 snRNA-specific, TUTase, TUTase6, U6-TUTase, URLC6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TUT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- Zinc-finger double-stranded RNA-binding
- nucleotidyltransferase
- U6 snRNA binding
- protein binding activity, bridging
- enzyme binding
- U1 zinc finger
- enzyme
- protein binding
- Zinc-finger of C2H2 type
- RNA binding
- Cid1 family poly A polymerase
- mRNA 3' UTR binding
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- RNA uridylyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
role in cell
- expression in
- accumulation in
- invasiveness
- 3' end processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TUT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snRNA processing
- histone mRNA catabolic process
- RNA 3'-end processing
- mRNA 3'-end processing
- U6 snRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- mRNA cleavage and polyadenylation specificity factor complex
- nuclear speck
- mitochondrion
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- RNA uridylyltransferase activity
- U6 snRNA binding
- protein binding
- RNA binding
- metal ion binding
- enzyme binding
- mRNA 3'-UTR binding