COPZ1 Gene Summary [Human]

This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Details

Type
Protein Coding
Official Symbol
COPZ1
Official Name
COPI coat complex subunit zeta 1 [Source:HGNC Symbol;Acc:HGNC:2243]
Ensembl ID
ENSG00000111481
Bio databases IDs NCBI: 22818 Ensembl: ENSG00000111481
Aliases COPI coat complex subunit zeta 1
Synonyms 5930435A22Rik, CGI-120, coatomer protein complex, subunit zeta 1, coatomer protein complex, subunit ζ 1, COPI coat complex subunit zeta 1, COPI coat complex subunit ζ 1, COPZ, Copz1 predicted, D4Ertd360e, HSPC181, Zeta-1 coat, zeta1-COP, zeta-COP, ζ-1 coat, ζ-COP
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COPZ1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Clathrin adaptor complex small chain
  • Longin-like domains
  • transporter

Pathways

Biological processes and signaling networks where the COPZ1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • glioblastoma
  • glioblastoma cancer
  • covid-19 death
  • venous thromboembolism
  • infection by lymphocytic choriomeningitis virus
  • infection by vesicular stomatitis virus
  • infection by Human parainfluenza virus 3
regulated by
regulates
role in cell
  • proliferation
  • apoptosis
  • number
  • growth
  • production in
  • size
  • killing
  • autophagy by
  • accumulation
  • accumulation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus
  • Golgi Apparatus
  • cytosol
  • endoplasmic reticulum membrane
  • Golgi membrane
  • transport vesicles

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human COPZ1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • retrograde vesicle-mediated transport, Golgi to ER
  • intra-Golgi vesicle-mediated transport
  • intracellular protein transport

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • cytosol
  • Golgi membrane
  • transport vesicle
  • COPI vesicle coat

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.