Copz1 Gene Summary [Mouse]
Predicted to be involved in intra-Golgi vesicle-mediated transport; intracellular protein transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi membrane. Predicted to be part of COPI vesicle coat. Orthologous to human COPZ1 (COPI coat complex subunit zeta 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Copz1 |
| Official Name | coatomer protein complex, subunit zeta 1 [Source:MGI Symbol;Acc:MGI:1929063] |
| Ensembl ID | ENSMUSG00000060992 |
| Bio databases IDs | |
| Aliases | coatomer protein complex, subunit zeta 1 |
| Synonyms | 5930435A22Rik, CGI-120, coatomer protein complex, subunit zeta 1, coatomer protein complex, subunit ζ 1, COPI coat complex subunit zeta 1, COPI coat complex subunit ζ 1, COPZ, Copz1 predicted, D4Ertd360e, HSPC181, Zeta-1 coat, zeta1-COP, zeta-COP, ζ-1 coat, ζ-COP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Copz1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Clathrin adaptor complex small chain
- Longin-like domains
- transporter
Pathways
Biological processes and signaling networks where the Copz1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioblastoma
- glioblastoma cancer
- covid-19 death
- venous thromboembolism
- infection by lymphocytic choriomeningitis virus
- infection by vesicular stomatitis virus
- infection by Human parainfluenza virus 3
role in cell
- proliferation
- apoptosis
- number
- growth
- production in
- size
- killing
- autophagy by
- accumulation
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- transport vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Copz1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retrograde vesicle-mediated transport, Golgi to ER
- intra-Golgi vesicle-mediated transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
- Golgi membrane
- transport vesicle
- COPI vesicle coat