HCFC2 Gene Summary [Human]
This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HCFC2 |
| Official Name | host cell factor C2 [Source:HGNC Symbol;Acc:HGNC:24972] |
| Ensembl ID | ENSG00000111727 |
| Bio databases IDs | |
| Aliases | host cell factor C2 |
| Synonyms | 1700129L13Rik, fkls, HCF-2, HOST CELL FACTOR 2, host cell factor C2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HCFC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- transcription regulator
- transcription co-activator
- FN3
- transcription cofactor
- transcription factor binding
- protein binding
- Fibronectin type 3 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HCFC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- viral reproduction
- regulation of transcription, DNA-dependent
- regulation of toll-like receptor 3 signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- Set1C/COMPASS complex
- nucleus
- nuclear body
- cytoplasm
- histone methyltransferase complex
- cytosol
- plasma membrane
- MLL1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity