KANSL2 Gene Summary [Human]
Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | KANSL2 |
| Official Name | KAT8 regulatory NSL complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:26024] |
| Ensembl ID | ENSG00000139620 |
| Bio databases IDs | |
| Aliases | KAT8 regulatory NSL complex subunit 2 |
| Synonyms | 2310037I24Rik, B930009D17, C12orf41, KAT8 regulatory NSL complex subunit 2, LOC103690317, NSL2, RGD1303127 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KANSL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Potential DNA-binding domain
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- actin cytoskeleton
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KANSL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- actin cytoskeleton
- cytosol
- NSL complex
- plasma membrane
- nucleoplasm
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- protein binding