CLEC4A Gene Summary [Human]
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CLEC4A |
| Official Name | C-type lectin domain family 4 member A [Source:HGNC Symbol;Acc:HGNC:13257] |
| Ensembl ID | ENSG00000111729 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 4 member A |
| Synonyms | CD367, CLECSF6, C-type lectin domain family 4 member A, DCIR, DDB27, HDCGC13P, hDCIR, LLIR |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLEC4A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- calcium ion binding
- Lectin C-type domain
- carbohydrate binding
- transmembrane receptor
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- atopic dermatitis
- diabetes mellitus
- peripheral arterial disease
- plasma cell myeloma
regulated by
- recombinant interferon gamma
- IL13
- Ebna3c
- Francisella tularensis subsp. holarctica LVS
- Human immunodeficiency virus type 1 NL4-3
- pervanadate
- fluticasone propionate
- HIV-1
- peripheral blood monocytes
role in cell
- production in
- phosphorylation in
- binding
- activation
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLEC4A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CD8-positive, alpha-beta T cell activation
- antigen processing and presentation of exogenous peptide antigen via MHC class I
- plasmacytoid dendritic cell antigen processing and presentation
- adaptive immune response
- cell adhesion
- cell surface receptor signaling pathway
- negative regulation of cytokine production
- negative regulation of tumor necrosis factor production
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- mannose binding
- calcium ion binding
- carbohydrate binding