CTNNA2 Gene Summary [Human]
Enables actin filament binding activity. Involved in negative regulation of Arp2/3 complex-mediated actin nucleation; regulation of neuron migration; and regulation of neuron projection development. Located in cytoplasm. Implicated in complex cortical dysplasia with other brain malformations. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CTNNA2 |
| Official Name | catenin alpha 2 [Source:HGNC Symbol;Acc:HGNC:2510] |
| Ensembl ID | ENSG00000066032 |
| Bio databases IDs | |
| Aliases | catenin alpha 2, cadherin-associated protein, related, cancer/testis antigen 114, alpha-N-catenin |
| Synonyms | alpha N-CATENIN, CAP-R, catenin alpha 2, catenin α 2, Catna, CATNA2, CDCBM9, cdf, chp, CT114, CTNR, LOC107985902, α N-CATENIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CTNNA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Vinculin family
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the CTNNA2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Alzheimer disease
- pachygyria
- stuttering
- complex cortical dysplasia with other brain malformations 9
- schizophrenia
- breast cancer
- acute myeloid leukemia
- subcutaneous hemangioma
- angiomatosis
role in cell
- migration
- morphology
- cell death
- abnormal morphology
- migration by
- arborization
- development
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum/Golgi apparatus fractions
- myelin enriched fraction
- synaptic plasma membrane fractions
- nuclear fraction
- postsynaptic density (PSD) fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- spot-like adhesion site
- organelle
- Cytoplasm
- presynaptic regions
- cytosol
- microsome
- basolateral membrane
- growth cone
- synaptosomes
- synapse
- anchoring junction
- axons
- postsynaptic density
- postsynaptic terminals
- excitatory synapses
- cell-cell adherens junctions
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CTNNA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- prepulse inhibition
- cytoskeleton organization
- axonogenesis
- radial glia guided migration of Purkinje cell
- brain morphogenesis
- regulation of neuron projection development
- cell migration
- regulation of neuron migration
- regulation of synapse structural plasticity
- negative regulation of Arp2/3 complex-mediated actin nucleation
- dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- adherens junction
- cytoplasm
- actin cytoskeleton
- cytosol
- catenin complex
- axon
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- cadherin binding
- structural constituent of cytoskeleton
- beta-catenin binding