SECTM1 Gene Summary [Human]
This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SECTM1 |
| Official Name | secreted and transmembrane 1 [Source:HGNC Symbol;Acc:HGNC:10707] |
| Ensembl ID | ENSG00000141574 |
| Bio databases IDs | |
| Aliases | secreted and transmembrane 1, K12 protein, type 1a transmembrane protein |
| Synonyms | K12, secreted and transmembrane 1, SECTM |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SECTM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- receptor agonist activity
- protein binding
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
- epileptic seizure
- skin basal cell carcinoma
- basal cell skin cancer
- prostate cancer
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- skin cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SECTM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- signal transduction
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- mesoderm development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity