CADM4 Gene Summary [Human]
Enables vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of protein phosphorylation; regulation of Rac protein signal transduction; and regulation of wound healing. Located in cell leading edge and cell-cell contact zone. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CADM4 |
| Official Name | cell adhesion molecule 4 [Source:HGNC Symbol;Acc:HGNC:30825] |
| Ensembl ID | ENSG00000105767 |
| Bio databases IDs | |
| Aliases | cell adhesion molecule 4, nectin-like 4 |
| Synonyms | cell adhesion molecule 4, Igdf4c, IGSF4C, Immunoglobulin superfamily, member 4c, NECL4, synCAM4, TSLL2, Upar |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CADM4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- putative band 4.1 homologues' binding motif
- cytoplasmic domain
- receptor tyrosine kinase binding
- Immunoglobulin V-Type
- immunoglobulin domain
- protein phosphatase binding
- ectodomain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- vascular endothelial growth factor receptor binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- motor dysfunction
- spatial memory impairment
- hypermyelination
role in cell
- proliferation
- formation
- adhesion
- morphology
- outfolding
- redistribution in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intercellular junctions
- synaptic membrane
- periaxonal membranes
- paranodal loops
- paranodes
- myelin sheath inner loop
- juxtaparanodes
- internodes
- Schmidt-Lanterman incisures
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CADM4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of vascular endothelial growth factor signaling pathway
- regulation of wound healing
- negative regulation of peptidyl-threonine phosphorylation
- regulation of protein phosphorylation
- regulation of Rac protein signal transduction
- negative regulation of protein phosphorylation
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- regulation of cell motility
- homophilic cell adhesion
- regulation of cell proliferation
- negative regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cell-cell contact zone
- cell leading edge
- membrane
Molecular Function
What the gene product does at the molecular level
- vascular endothelial growth factor receptor 1 binding
- protein phosphatase binding
- vascular endothelial growth factor receptor 2 binding
- receptor tyrosine kinase binding