MDN1 Gene Summary [Human]
Predicted to enable ATP binding activity. Involved in ribosomal large subunit assembly. Located in cytosol; intermediate filament cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MDN1 |
| Official Name | midasin AAA ATPase 1 [Source:HGNC Symbol;Acc:HGNC:18302] |
| Ensembl ID | ENSG00000112159 |
| Bio databases IDs | |
| Aliases | midasin AAA ATPase 1 |
| Synonyms | 4833432B22RIK, A130070M06, D4Abb1e, Gm135, Midasin, midasin AAA ATPase 1, Rea1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MDN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA domain (dynein-related subfamily)
- Midasin AAA lid domain
- ATPase family associated with various cellular activities (AAA)
- von Willebrand factor (vWF) type A domain
- vWFA
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- IgA nephropathy
- non-small cell lung cancer
- rheumatic disease
- infectious mononucleosis
- endometrial carcinoma
- epithelial endometrial cancer
- productive infection by HIV-1
regulates
- Ribosomal Subunit 60s
role in cell
- apoptosis
- number
- synthesis in
- necroptosis
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intermediate filament cytoskeleton
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MDN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal large subunit export from nucleus
- ribosomal large subunit assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- intermediate filament cytoskeleton
- membrane
- cytosol
- nucleolus
- nucleoplasm
- preribosome, large subunit precursor
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding