ZNF451 Gene Summary [Human]
Enables SUMO ligase activity and transcription corepressor activity. Involved in negative regulation of nitrogen compound metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF451 |
| Official Name | zinc finger protein 451 [Source:HGNC Symbol;Acc:HGNC:21091] |
| Ensembl ID | ENSG00000112200 |
| Bio databases IDs | |
| Aliases | zinc finger protein 451, zinc finger protein associated with TDP2 and TOP2 |
| Synonyms | 4930515K21Rik, 4933435G09Rik, AI596398, COASTER, dJ417I1.1, Kiaa0576-hp, KIAA1702, LOC100506156, LOC100509219, mKIAA1702, ZATT, Zfp451, zinc finger protein 451 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF451 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO ligase
- PIN like domain
- transcription co-repressor
- enzyme
- protein binding
- PIN (PilT N terminus) domain: Superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- exhaustion
- aortic valve calcification
- organismal death
- breast cancer
- Hutchinson-Gilford progeria syndrome
role in cell
- expression in
- growth
- transcription in
- morphology
- sumoylation in
- condensation in
- ubiquitination in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF451 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- negative regulation of transcription initiation from RNA polymerase II promoter
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transcription corepressor activity
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity