ELF4 Gene Summary [Human]
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | ELF4 |
| Official Name | E74 like ETS transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:3319] |
| Ensembl ID | ENSG00000102034 |
| Bio databases IDs | |
| Aliases | E74 like ETS transcription factor 4 |
| Synonyms | AIFBL2, AV314029, BC042423, E74 like ETS transcription factor 4, ELFR, Gm9907, MEF, MEF1, MYELOID ELF-1-LIKE FACTOR, RGD1560743 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ELF4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- AML1-binding domain
- nucleic acid binding
- double-stranded DNA binding
- Ets-domain
- protein binding
- sequence-specific DNA binding
- Transcription factor protein N terminal
Pathways
Biological processes and signaling networks where the ELF4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ischemia/reperfusion-induced acute kidney injury
- colitis
- X-linked familial Behcet-like autoinflammatory syndrome-2
- HER2 negative hormone receptor negative breast cancer
- malarial anemia
- parasitemia
- neoplastic cell transformation
- peripheral arterial disease
- diabetes mellitus
role in cell
- migration
- cell viability
- expression in
- proliferation
- apoptosis
- quantity
- degradation in
- maturation
- number
- pyroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear bodies
- PML nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ELF4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- natural killer cell proliferation
- NK T cell proliferation
- positive regulation of transcription, DNA-dependent
- negative regulation of inflammatory response
- negative regulation of interleukin-1 beta production
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of tumor necrosis factor production
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PML body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity