MAVS Gene Summary [Human]
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral innate immunity. [provided by RefSeq, Jul 2020]
Details
| Type | Protein Coding |
| Official Symbol | MAVS |
| Official Name | mitochondrial antiviral signaling protein [Source:HGNC Symbol;Acc:HGNC:29233] |
| Ensembl ID | ENSG00000088888 |
| Bio databases IDs | |
| Aliases | mitochondrial antiviral signaling protein, virus-induced signaling adaptor, IFN-B promoter stimulator 1, CARD adaptor inducing IFN-beta |
| Synonyms | CARDIF, D430028G21Rik, IPS-1, KIAA1271, MGC3260, mitochondrial antiviral signaling protein, VISA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAVS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- traf2 binding domain
- protein kinase binding
- Traf2/3 binding domain
- protein binding activity, bridging
- transcription factor binding
- protein binding
- receptor binding
- identical protein binding
- effector domain
- proline rich domain
- TRAF6 binding domain
- Caspase recruitment domain
- CARD-like domain
- TRAF binding domain
- C-terminal transmembrane domain
- transmembrane domain
- pro domain
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the MAVS gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- aortic calcification
- myocarditis
- airway hyperresponsiveness
- paralysis
- epithelial hyperplasia
- complete testicular feminization syndrome
- vasculitis
role in cell
- activation in
- cell death
- activation
- expression in
- accumulation in
- phosphorylation in
- loss
- aggregation in
- apoptosis
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- insoluble fractions
- outer membranes
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- mitochondrial membrane
- mitochondrial outer membrane
- peroxisome membrane
- peroxisomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAVS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of response to cytokine stimulus
- positive regulation of type I interferon-mediated signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- cytoplasmic pattern recognition receptor signaling pathway
- positive regulation of interferon-alpha production
- positive regulation of chemokine (C-C motif) ligand 5 production
- activation of innate immune response
- protein localization in mitochondrion
- positive regulation of myeloid dendritic cell cytokine production
- positive regulation of interferon-beta production
- defense response to virus
- positive regulation of tumor necrosis factor production
- negative regulation of viral genome replication
- regulation of peroxisome organization
- positive regulation of protein import into nucleus
- signal transduction
- positive regulation of type I interferon production
- negative regulation of type I interferon-mediated signaling pathway
- positive regulation of defense response to virus by host
- positive regulation of NLRP3 inflammasome complex assembly
- defense response to bacterium
- type I interferon-mediated signaling pathway
- positive regulation of interleukin-8 production
- cellular response to exogenous dsRNA
- positive regulation of IP-10 production
- innate immune response
- positive regulation of protein phosphorylation
- positive regulation of interleukin-6 production
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- mitochondrial membrane
- ubiquitin ligase complex
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- signaling adaptor activity
- RIG-I binding
- CARD domain binding
- binding, bridging