DUSP22 Gene Summary [Human]
Enables non-membrane spanning protein tyrosine phosphatase activity and protein tyrosine kinase binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of focal adhesion assembly; and negative regulation of non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in plasma membrane. Part of cytoplasm; filamentous actin; and leading edge of lamellipodium. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DUSP22 |
| Official Name | dual specificity phosphatase 22 [Source:HGNC Symbol;Acc:HGNC:16077] |
| Ensembl ID | ENSG00000112679 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 22 |
| Synonyms | dual specificity phosphatase 22, Dusp22 predicted, JKAP, JSP-1, LMW-DSP2, LOC100134291, LOC100134371, LOC100509491, MKP-x, VHX |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DUSP22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- non-membrane spanning protein tyrosine phosphatase
- protein kinase binding
- protein tyrosine/serine/threonine phosphatase
- protein-tyrosine-phoshatase
- protein tyrosine kinase inhibitor activity
- phosphatase
- PTP_DSP_cys
- protein binding
Pathways
Biological processes and signaling networks where the DUSP22 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- autoimmune disease
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- ALK negative anaplastic large cell lymphoma
- lymphomatoid papulosis
- Takayasu arteritis
- alopecia
- experimental autoimmune encephalomyelitis
- soft tissue sarcoma
role in cell
- phosphorylation in
- activation in
- proliferation
- growth
- expression in
- migration
- survival
- activation
- assembly
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- actin filaments
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DUSP22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- transforming growth factor beta receptor signaling pathway
- regulation of cell proliferation
- negative regulation of focal adhesion assembly
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of T cell mediated immunity
- negative regulation of T cell receptor signaling pathway
- positive regulation of JNK cascade
- cellular response to epidermal growth factor stimulus
- negative regulation of T cell activation
- dephosphorylation
- peptidyl-tyrosine dephosphorylation
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- filamentous actin
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- myosin phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity