EIF4E2 Gene Summary [Human]
Enables ubiquitin protein ligase binding activity. Involved in positive regulation of miRNA mediated inhibition of translation. Acts upstream of or within negative regulation of translation. Located in P-body. Part of mRNA cap binding activity complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EIF4E2 |
| Official Name | eukaryotic translation initiation factor 4E family member 2 [Source:HGNC Symbol;Acc:HGNC:3293] |
| Ensembl ID | ENSG00000135930 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4E family member 2 |
| Synonyms | 2700069E09Rik, 4EHP, 4E-LP, AI036339, D0H0S6743E, EIF4EL3, eIF-4E type 3, eukaryotic translation initiation factor 4E family member 2, eukaryotic translation initiation factor 4E member 2, h4EHP, IF4e, LOC100507948, LOC683250 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF4E2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- nucleic acid binding translation factor
- Eukaryotic initiation factor 4E
- RNA 7-methylguanosine cap binding
- RNA cap binding
- mRNA binding
- protein binding
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- non-small cell lung carcinoma
- organismal death
- cyanosis
- survival
- respiratory failure
- infection by human herpesvirus 1
role in cell
- production in
- replication in
- cohesion
- translation in
- cohesion in
- translational silencing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF4E2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- negative regulation of translational initiation
- rescue of stalled ribosome
- negative regulation of type I interferon-mediated signaling pathway
- translational initiation
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- eukaryotic translation initiation factor 4F complex
- cytoplasm
- cytosol
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA 7-methylguanosine cap binding
- ubiquitin protein ligase binding
- protein binding
- RNA binding
- RNA cap binding
- translation factor activity, nucleic acid binding