NME5 Gene Summary [Human]
Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and spermatid development. Predicted to act upstream of or within cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and ventricular system development. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NME5 |
| Official Name | NME/NM23 family member 5 [Source:HGNC Symbol;Acc:HGNC:7853] |
| Ensembl ID | ENSG00000112981 |
| Bio databases IDs | |
| Aliases | NME/NM23 family member 5, radial spoke 23 homolog (Chlamydomonas) |
| Synonyms | 1700019D05Rik, CILD48, NM23-H5, Nm23-M5, NME/NM23 family member 5, RSPH23 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NME5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleoside diphosphate kinase
- 3'-5' exonuclease
- Nucleoside diphosphate kinase family
- NDPk
- protein binding
- DD_R_PKA_DPY30-like
- Dpy-30 motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- hydrocephalus
- primary ciliary dyskinesia type 48 without situs inversus
- diabetes mellitus
- azoospermia
- intraventricular hemorrhage
regulates
- nucleoside
role in cell
- assembly
- development
- abnormal morphology
- movement
- detachment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NME5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular system development
- UTP biosynthetic process
- cilium morphogenesis
- CTP biosynthetic process
- spermatid development
- spermatogenesis
- GTP biosynthetic process
- nucleoside metabolic process
- epithelial cilium movement
- cilium movement
- establishment of localization in cell
Cellular Component
Where in the cell the gene product is active
- radial spoke
- cilium
- sperm flagellum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- 3'-5' exonuclease activity
- protein binding
- nucleoside diphosphate kinase activity