Nme5 Gene Summary [Mouse]
Predicted to enable 3'-5' exonuclease activity. Involved in spermatid development. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and ventricular system development. Located in sperm flagellum. Part of radial spoke. Is expressed in lung epithelium; nasal cavity respiratory epithelium; and nasopharynx epithelium. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human NME5 (NME/NM23 family member 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Nme5 |
| Official Name | NME/NM23 family member 5 [Source:MGI Symbol;Acc:MGI:1922783] |
| Ensembl ID | ENSMUSG00000035984 |
| Bio databases IDs | |
| Aliases | NME/NM23 family member 5 |
| Synonyms | 1700019D05Rik, CILD48, NM23-H5, Nm23-M5, NME/NM23 family member 5, RSPH23 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nme5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleoside diphosphate kinase
- 3'-5' exonuclease
- Nucleoside diphosphate kinase family
- NDPk
- protein binding
- DD_R_PKA_DPY30-like
- Dpy-30 motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- hydrocephalus
- primary ciliary dyskinesia type 48 without situs inversus
- diabetes mellitus
- azoospermia
- intraventricular hemorrhage
regulates
- nucleoside
role in cell
- assembly
- development
- abnormal morphology
- movement
- detachment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nme5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular system development
- UTP biosynthetic process
- cilium morphogenesis
- CTP biosynthetic process
- spermatid development
- spermatogenesis
- GTP biosynthetic process
- nucleoside metabolic process
- epithelial cilium movement
- cilium movement
- establishment of localization in cell
Cellular Component
Where in the cell the gene product is active
- radial spoke
- cilium
- sperm flagellum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- 3'-5' exonuclease activity
- protein binding
- nucleoside diphosphate kinase activity