NFIC Gene Summary [Human]
The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | NFIC |
| Official Name | nuclear factor I C [Source:HGNC Symbol;Acc:HGNC:7786] |
| Ensembl ID | ENSG00000141905 |
| Bio databases IDs | |
| Aliases | nuclear factor I C, CCAAT-binding transcription factor |
| Synonyms | 1110019L22RIK, 1500041O16RIK, CTF, CTF5, NF1-C, Nf1-C2, Nf1/ctf, NF-I, NFI/CTF-1, Nfic variant 1, Nuclear factor 1/C, nuclear factor I C, nuclear factor I/C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFIC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- N-terminal Mad Homology 1 (MH1) domain
- DNA binding
- Nuclear factor I protein pre-N-terminus
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- MH1 domain
- CTF/NF-I family transcription modulation region
- transcription factor activity
Pathways
Biological processes and signaling networks where the NFIC gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- nonalcoholic fatty liver disease
- cutaneous melanoma
- male pattern hair loss
- acute myeloid leukemia
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- adenomyosis
- plasma cell myeloma
role in cell
- proliferation
- expression in
- activation in
- accumulation in
- apoptosis
- G2/M phase
- growth
- transactivation in
- differentiation
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFIC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- DNA replication
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity