Rnf130 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Involved in programmed cell death. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; male reproductive system; pancreas; retina; and urinary system. Orthologous to human RNF130 (ring finger protein 130). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf130 |
| Official Name | ring finger protein 130 [Source:MGI Symbol;Acc:MGI:1891717] |
| Ensembl ID | ENSMUSG00000020376 |
| Bio databases IDs | |
| Aliases | ring finger protein 130 |
| Synonyms | 2510042A13Rik, G1RP, G1RZFP, GOLIATH, GP, LOC552912, ring finger protein 130 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf130 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- PA
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- peptidase
- ubiquitin-protein transferase activity
- Ring finger domain
- RING-like zinc finger
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- Alzheimer disease
- microgliosis
- diabetes mellitus
- memory deficits
- glioma formation
- pilocytic astrocytoma
regulates
- MAPT
- calcineurin (family)
role in cell
- activation
- apoptosis
- glycolysis in
- deubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- flagella
- Mitochondria
- mitochondrial inner membrane
- residual bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf130 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- programmed cell death
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- metal ion binding