THG1L Gene Summary [Human]
The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | THG1L |
| Official Name | tRNA-histidine guanylyltransferase 1 like [Source:HGNC Symbol;Acc:HGNC:26053] |
| Ensembl ID | ENSG00000113272 |
| Bio databases IDs | |
| Aliases | tRNA-histidine guanylyltransferase 1 like, interphase cytoplasmic foci protein 45, induced by high glucose-1 |
| Synonyms | hTHG1, ICF45, IHG-1, SCAR28, THG1, tRNA-histidine guanylyltransferase 1-like, tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THG1L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- tRNA binding
- tRNAHis guanylyltransferase
- nucleotidyltransferase
- guanyl-nucleotide exchange factor
- Thg1 C terminal domain
- ATP binding
- tRNA guanylyltransferase
- enzyme
- protein binding
- magnesium ion binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- Mitochondria
- cytoplasmic aggregates
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THG1L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- protein homotetramerization
- tRNA processing
- mitochondrial fusion
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- magnesium ion binding
- ATP binding
- identical protein binding
- tRNA guanylyltransferase activity
- nucleotidyltransferase activity
- protein binding
- guanyl-nucleotide exchange factor activity
- tRNA binding