MAFB Gene Summary [Human]
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAFB |
| Official Name | MAF bZIP transcription factor B [Source:HGNC Symbol;Acc:HGNC:6408] |
| Ensembl ID | ENSG00000204103 |
| Bio databases IDs | |
| Aliases | MAF bZIP transcription factor B |
| Synonyms | Basic domain/leucine zipper transcription factor, b-maf, DURS3, kr, Kreisler, KRML, Krml1, Maf1, MAF bZIP transcription factor B, MCTO |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAFB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- Maf N-terminal region
- transcription regulator
- Sumoylation motif
- nucleic acid binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- binding protein
- double-stranded DNA binding
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the MAFB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteosarcoma
- duane retraction syndrome 3
- atherosclerosis
- hereditary disorder
- multicentric carpotarsal osteolysis syndrome
- cyanosis
- metastatic colorectal cancer
- dyspnea
- orofacial cleft 1
role in cell
- migration
- apoptosis
- expression in
- growth
- proliferation
- differentiation
- activation in
- production in
- quantity
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAFB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell differentiation in thymus
- brain segmentation
- abducens nerve formation
- regulation of transcription, DNA-dependent
- fat cell differentiation
- respiratory gaseous exchange
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of erythrocyte differentiation
- regulation of myeloid cell differentiation
- segment specification
- sensory organ development
- thymus development
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- keratinocyte differentiation
- rhombomere 5 development
- rhombomere 6 development
- positive regulation of transcription, DNA-dependent
- inner ear morphogenesis
- negative regulation of osteoclast differentiation
- protein processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity