ARRDC3 Gene Summary [Human]
This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | ARRDC3 |
| Official Name | arrestin domain containing 3 [Source:HGNC Symbol;Acc:HGNC:29263] |
| Ensembl ID | ENSG00000113369 |
| Bio databases IDs | |
| Aliases | arrestin domain containing 3, alpha-arrestin 3, TBP-2-like inducible membrane protein |
| Synonyms | arrestin domain containing 3, KIAA1376, LRRGT00048, mKIAA1376, TLIMP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARRDC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arrestin (or S-antigen), C-terminal domain
- PPXY motif
- G-protein-coupled receptor binding
- protein binding
- Arrestin (or S-antigen), N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mammary neoplasm
- epileptic seizure
role in cell
- phosphorylation in
- proliferation
- migration
- invasion by
- ubiquitination in
- interaction in
- growth
- degradation in
- transcription in
- budding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endosomes
- cell membrane-lagging edges
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARRDC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heat generation
- negative regulation of locomotion involved in locomotory behavior
- positive regulation of hippo signaling cascade
- positive regulation of ubiquitin-protein ligase activity
- protein transport
- negative regulation of heat generation
- fat pad development
- skin development
- negative regulation of adrenergic receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- cytoplasm
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-3 adrenergic receptor binding