F2R Gene Summary [Human]
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | F2R |
| Official Name | coagulation factor II thrombin receptor [Source:HGNC Symbol;Acc:HGNC:3537] |
| Ensembl ID | ENSG00000181104 |
| Bio databases IDs | |
| Aliases | coagulation factor II thrombin receptor, protease activated receptor 1 |
| Synonyms | CF2R, coagulation factor II (thrombin) receptor, coagulation factor II thrombin receptor, HTR, PAR-1, ThrR, TR, TRGPC, α Thrombin Receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human F2R often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- activation domain
- intracellular loop
- thrombin receptor
- Cholecystokinin A receptor, N-terminal
- alpha helix
- protein binding
- receptor binding
- cleavage site
- seven-transmembrane G protein-coupled receptor superfamily
- phosphorylation site
- binding protein
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- cytosolic tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the F2R gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Breast Cancer Regulation by Stathmin1
- Cellular Effects of Sildenafil (Viagra)
- Clathrin-mediated Endocytosis Signaling
- Coagulation System
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Glioma Invasiveness Signaling
- Granzyme A Signaling
- Gα12/13 Signaling
- Molecular Mechanisms of Cancer
- p70S6K Signaling
- Phagosome Formation
- Role of Tissue Factor in Cancer
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cognitive impairment
- neoplasia
- cancer
- weight gain
- peripheral vascular disease
- ischemic stroke
- metastasis
- thromboembolism
- myocarditis
- venous thromboembolism
role in cell
- formation
- expression in
- function
- proliferation
- migration
- chemotaxis
- survival
- morphology
- growth
- secretion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- intracellular compartment
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- cellular membrane
- Golgi Apparatus
- postsynaptic membrane
- caveolae
- neuromuscular junctions
- early endosomes
- late endosomes
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human F2R gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- positive regulation of blood coagulation
- regulation of blood coagulation
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- positive regulation of vasoconstriction
- positive regulation of calcium ion transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- response to wounding
- negative regulation of renin secretion into blood stream
- anatomical structure morphogenesis
- positive regulation of GTPase activity
- negative regulation of neuron apoptotic process
- positive regulation of smooth muscle contraction
- establishment of synaptic specificity at neuromuscular junction
- negative regulation of glomerular filtration
- inflammatory response
- positive regulation of collagen biosynthetic process
- positive regulation of transcription, DNA-dependent
- regulation of synaptic plasticity
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- release of sequestered calcium ion into cytosol
- platelet activation
- dendritic cell homeostasis
- platelet dense granule organization
- G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of release of sequestered calcium ion into cytosol
- protein kinase C-activating G-protein coupled receptor signaling pathway
- positive regulation of JAK-STAT cascade
- cell-cell junction maintenance
- elevation of cytosolic calcium ion concentration
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- thrombin receptor signaling pathway
- positive regulation of interleukin-8 production
- connective tissue replacement involved in inflammatory response wound healing
- homeostasis of number of cells within a tissue
- positive regulation of ERK1 and ERK2 cascade
- response to lipopolysaccharide
- regulation of interleukin-1 beta production
- positive regulation of interleukin-6 production
- positive regulation of protein kinase B signaling cascade
- regulation of sensory perception of pain
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- platelet dense tubular network
- early endosome
- caveola
- postsynaptic membrane
- late endosome
- Golgi apparatus
- neuromuscular junction
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- thrombin receptor activity
- protein binding
- G-protein beta-subunit binding
- G-protein alpha-subunit binding
- receptor binding