MCM5
MCM5 Gene Summary
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | MCM5 |
| Official Name | minichromosome maintenance complex component 5 [Source:HGNC Symbol;Acc:HGNC:6948] |
| Ensembl ID | ENSG00000100297 |
| Bio databases IDs | |
| Aliases | minichromosome maintenance complex component 5 |
| Synonyms | CDC46,Mcmd5,MGORS8,minichromosome maintenance complex component 5,P1-CDC46 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase domain
- minichromosome maintenance proteins
- MCM OB domain
- ATP-binding domain
- ATPase domain
- MCM N-terminal domain
- MCM P-loop domain
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- MCM AAA-lid domain
- MCM helicase family
Pathways
Biological processes and signaling networks where the MCM5 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR1
- ESR2
- histone H3
- FANCD2
- PRC1
- PCBP1
- DICER1
- ARRDC3
- RPA2
- DVL2
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- Meier-Gorlin syndrome type 8
- cervical cancer
- psoriatic arthritis
- colon cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- plexiform neurofibroma
regulated by
- beta-estradiol
- lipopolysaccharide
- TNF
- fulvestrant
- TP53
- calcitriol
- HL 60 cells
- CEBPB
- dihydrotestosterone
- TFEB
regulates
- NOTCH1
- STAT1
- reporter gene
role in cell
- growth
- migration
- survival
- invasion by
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- cytosol
- nucleoplasm
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MCM5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- double-strand break repair via break-induced replication
- DNA replication
- regulation of DNA-dependent DNA replication initiation
- DNA unwinding involved in replication
CELLULAR COMPONENT
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- CMG complex
- membrane
- MCM complex
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA replication origin binding
- protein binding
- 3'-5' DNA helicase activity
- single-stranded DNA-dependent ATP-dependent DNA helicase activity
- single-stranded DNA binding