ARR3 Gene Summary [Human]
The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]
Details
| Type | Protein Coding |
| Official Symbol | ARR3 |
| Official Name | arrestin 3 [Source:HGNC Symbol;Acc:HGNC:710] |
| Ensembl ID | ENSG00000120500 |
| Bio databases IDs | |
| Aliases | arrestin 3, arrestin 4, cone arrestin |
| Synonyms | Arr4, arrestin 3, arrestin 3, retinal, ARRX, Car, Carfl, Carr, C-ARRESTIN, MYP26, Visual arrestin, X-arrestin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arrestin (or S-antigen), C-terminal domain
- receptor binding domain
- clathrin binding domain
- coated pit binding domain
- phosphoprotein binding
- protein domain specific binding
- protein binding
- Arrestin (or S-antigen), N-terminal domain
- Ap-2 binding domain
Pathways
Biological processes and signaling networks where the ARR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- female-limited X-linked myopia 26
- spinocerebellar ataxia type 7
role in cell
- apoptosis
- activation in
- quantity
- cell rounding
- internalization by
- response in
- clustering
- mobilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nerve ending
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- perikaryon
- cone outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein phosphorylation
- signal transduction
- G-protein coupled receptor internalization
- visual perception
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- synapse
- photoreceptor inner segment
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- phosphoprotein binding
- opsin binding