USP9Y Gene Summary [Human]
This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. [provided by RefSeq, Mar 2009]
Details
| Type | Processed Transcript |
| Official Symbol | USP9Y |
| Official Name | ubiquitin specific peptidase 9 Y-linked [Source:HGNC Symbol;Acc:HGNC:12633] |
| Ensembl ID | ENSG00000114374 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 9 Y-linked, fat facets-like homolog (Drosophila), azoospermia factor A |
| Synonyms | AZF1, DFFRY, FAF-Y, SPGFY2, ubiquitin specific peptidase 9 Y-linked |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP9Y often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF3517)
- SMAD binding
- ubiquitin thiolesterase
- cysteine-type peptidase
- Ubl1_cv_Nsp3_N-like
- peptidase
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
- Peptidase_C19
Pathways
Biological processes and signaling networks where the USP9Y gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP9Y gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- spermatogenesis
- BMP signaling pathway
- proteolysis
- transforming growth factor beta receptor signaling pathway
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- metal ion binding
- co-SMAD binding
- cysteine-type peptidase activity