PGAM1 Gene Summary [Human]
The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | PGAM1 |
| Official Name | phosphoglycerate mutase 1 [Source:HGNC Symbol;Acc:HGNC:8888] |
| Ensembl ID | ENSG00000171314 |
| Bio databases IDs | |
| Aliases | phosphoglycerate mutase 1, Phosphoglycerate mutase A, nonmuscle form |
| Synonyms | 2310050F24Rik, HEL-S-35, PGAMA, PGAM-B, Pgmut, phosphoglycerate mutase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PGAM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- bisphosphoglycerate phosphatase
- phosphoglycerate mutase
- phosphatase
- bisphosphoglycerate mutase
- protein binding
- alpha-ribazole phosphatase
- Histidine phosphatase domain
Pathways
Biological processes and signaling networks where the PGAM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- tumorigenesis
- schizophrenia
- papillary thyroid carcinoma
- hepatocellular carcinoma
- papillary thyroid cancer
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
role in cell
- invasion by
- migration
- proliferation
- formation
- formation in
- recruitment in
- gluconeogenesis in
- biosynthesis in
- double-stranded DNA break repair in
- homologous recombination repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PGAM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- bisphosphoglycerate mutase activity
- phosphoglycerate mutase activity
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
- hydrolase activity