PRAM1 Gene Summary [Human]
The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | PRAM1 |
| Official Name | PML-RARA regulated adaptor molecule 1 [Source:HGNC Symbol;Acc:HGNC:30091] |
| Ensembl ID | ENSG00000133246 |
| Bio databases IDs | |
| Aliases | PML-RARA regulated adaptor molecule 1 |
| Synonyms | AY665714, PML-RAR alpha-regulated adaptor molecule 1, PML-RARA regulated adaptor molecule 1, PML-RAR α-regulated adaptor molecule 1, RGD1564330 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRAM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein binding
- Helically-extended SH3 domain
- Sh3 domain binding motif
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRAM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- integrin-mediated signaling pathway
- regulation of neutrophil degranulation
- T cell receptor signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- lipid binding