Igfbp2 Gene Summary [Rat]
Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including response to estradiol; response to estrogen; and response to retinoic acid. Located in apical plasma membrane and extracellular space. Biomarker of hypertension and hypothyroidism. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igfbp2 |
| Official Name | insulin-like growth factor binding protein 2 [Source:RGD Symbol;Acc:2873] |
| Ensembl ID | ENSRNOG00000016957 |
| Bio databases IDs | |
| Aliases | insulin-like growth factor binding protein 2 |
| Synonyms | BRL-BP, IBP-2, IGF-BP53, ILGFBPA, insulin-like growth factor binding protein 2, mIGFBP-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Igfbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- TY
- RGD motif
- heparin binding domain
- insulin-like growth factor binding
- receptor inhibitor
- linker domain
- protein binding
- receptor binding
- Insulin-like growth factor binding protein
Pathways
Biological processes and signaling networks where the Igfbp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- major depression
- neoplasia
- obesity
- epithelial cancer
- cancer
- liver cancer
- metastasis
- HER2 negative hormone receptor negative breast cancer
- glioblastoma
role in cell
- formation
- growth
- expression in
- production in
- accumulation in
- differentiation
- binding
- cell death
- activation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- perinuclear region
- Nucleus
- apical membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Igfbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- female pregnancy
- response to nutrient
- response to xenobiotic stimulus
- regulation of insulin-like growth factor receptor signaling pathway
- positive regulation of activated T cell proliferation
- response to mechanical stimulus
- negative regulation of canonical Wnt receptor signaling pathway
- response to retinoic acid
- response to glucocorticoid stimulus
- response to estradiol stimulus
- cellular response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding
- insulin-like growth factor I binding
- insulin-like growth factor II binding