DCAF17 Gene Summary [Human]
This gene encodes a nuclear transmembrane protein that associates with cullin 4A/damaged DNA binding protein 1 ubiquitin ligase complex. Mutations in this gene are associated with Woodhouse-Sakati syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Details
| Type | Processed Transcript |
| Official Symbol | DCAF17 |
| Official Name | DDB1 and CUL4 associated factor 17 [Source:HGNC Symbol;Acc:HGNC:25784] |
| Ensembl ID | ENSG00000115827 |
| Bio databases IDs | |
| Aliases | DDB1 and CUL4 associated factor 17, Woodhouse-Sakati syndrome |
| Synonyms | 2810055O12Rik, 4833418A01Rik, A030004A10Rik, A930009G19Rik, C20orf37, C2orf37, DDB1 and CUL4 associated factor 17, RGD1565551 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCAF17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DDB1- and CUL4-associated factor 17
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCAF17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- nucleolus
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding