Dcaf17 Gene Summary [Rat]

Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within acrosome assembly and cell morphogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in Woodhouse-Sakati syndrome. Orthologous to human DCAF17 (DDB1 and CUL4 associated factor 17). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Dcaf17
Official Name
DDB1 and CUL4 associated factor 17 [Source:RGD Symbol;Acc:1565551]
Ensembl ID
ENSRNOG00000009403
Bio databases IDs NCBI: 499807 Ensembl: ENSRNOG00000009403
Aliases DDB1 and CUL4 associated factor 17
Synonyms 2810055O12Rik, 4833418A01Rik, A030004A10Rik, A930009G19Rik, C20orf37, C2orf37, DDB1 and CUL4 associated factor 17, RGD1565551
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dcaf17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • DDB1- and CUL4-associated factor 17
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Woodhouse-Sakati syndrome
  • neurodegeneration with brain iron accumulation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Dcaf17 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • protein ubiquitination

Cellular Component

Where in the cell the gene product is active
  • membrane
  • cytosol
  • nucleolus
  • CUL4 RING ubiquitin ligase complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.