CUL5 Gene Summary [Human]
Enables ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within cerebral cortex radially oriented cell migration and radial glia guided migration of Purkinje cell. Located in site of DNA damage. Part of Cul5-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CUL5 |
| Official Name | cullin 5 [Source:HGNC Symbol;Acc:HGNC:2556] |
| Ensembl ID | ENSG00000166266 |
| Bio databases IDs | |
| Aliases | cullin 5 |
| Synonyms | 4921514I20Rik, 8430423K24Rik, C030032G03Rik, C330021I08Rik, cullin 5, VACM-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CUL5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- signaling receptor activity
- vasopressin receptor
- calcium channel
- ubiquitin-protein transferase activity
- protein binding activity, bridging
- Cullin protein neddylation domain
- Cullin family
- protein binding
- ion channel
- Cullin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- airway hyperresponsiveness
- luminal A breast carcinoma
- luminal A breast cancer
- hyperplasia
- scarlet fever
- infection by vesicular stomatitis virus
role in cell
- differentiation
- proliferation
- apoptosis
- migration
- cellular infiltration by
- accumulation
- expression in
- production in
- quantity
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CUL5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G1/S transition of mitotic cell cycle
- calcium ion transmembrane transport
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- intrinsic apoptotic signaling pathway
- ERBB2 signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- SCF ubiquitin ligase complex
- Cul5-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- ubiquitin protein ligase binding
- calcium channel activity
- signaling receptor activity
- protein binding, bridging