PREX1 Gene Summary [Human]
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PREX1 |
| Official Name | phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:32594] |
| Ensembl ID | ENSG00000124126 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1, PIP3 dependent Rac exchange factor 1 |
| Synonyms | G630042G04, LOC105372648, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1, PREX1 isoform 1, RGD1306534, Setd6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PREX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- phospholipid binding
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- enzyme binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- DEP
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- Dbl homology domain
Pathways
Biological processes and signaling networks where the PREX1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- Alzheimer disease
- colorectal cancer
- postmenopausal osteoporosis
- experimentally induced airway hyperresponsiveness
- pervasive developmental disorder
- colorectal adenoma
- colorectal adenoma formation
- plasma cell myeloma
role in cell
- apoptosis
- cell viability
- phosphorylation in
- expression in
- formation
- formation in
- cellular infiltration by
- transmigration
- motility
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
- neurite stump
- growth cone
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PREX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neutrophil activation
- G-protein coupled receptor signaling pathway
- actin filament polymerization
- positive regulation of substrate adhesion-dependent cell spreading
- positive regulation of GTPase activity
- regulation of actin filament polymerization
- T cell differentiation
- regulation of dendrite development
- superoxide metabolic process
- regulation of signaling
- regulation of small GTPase mediated signal transduction
- neutrophil chemotaxis
- intracellular signal transduction
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- growth cone
- perinuclear region of cytoplasm
- dendritic shaft
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- GTPase activator activity
- phospholipid binding
- enzyme binding