KYNU Gene Summary [Human]
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | KYNU |
| Official Name | kynureninase [Source:HGNC Symbol;Acc:HGNC:6469] |
| Ensembl ID | ENSG00000115919 |
| Bio databases IDs | |
| Aliases | kynureninase, L-kynurenine hydrolase |
| Synonyms | 4432411A05Rik, KYNURENINASE, KYNUU, l-kynurenine hydrolase, VCRL2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KYNU often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pyridoxal phosphate binding
- protein homodimerization
- enzyme
- protein binding
- kynureninase
Pathways
Biological processes and signaling networks where the KYNU gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- vertebral, cardiac, renal, and limb defects syndrome 2
- organismal death
- periodontitis
- idiopathic scoliosis
- diabetic nephropathy
- kynureninase deficiency
- asthma
- Catel-Manzke syndrome
- Behcet disease
role in cell
- invasion by
- apoptosis
- proliferation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KYNU gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tryptophan catabolic process
- quinolinate biosynthetic process
- de novo NAD biosynthetic process from tryptophan
- tryptophan catabolic process to kynurenine
- response to interferon-gamma
- anthranilate metabolic process
- NAD biosynthetic process
- response to vitamin B6
- L-kynurenine catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- protein homodimerization activity
- kynureninase activity