TNR Gene Summary [Human]
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | TNR |
| Official Name | tenascin R [Source:HGNC Symbol;Acc:HGNC:11953] |
| Ensembl ID | ENSG00000116147 |
| Bio databases IDs | |
| Aliases | tenascin R, restrictin, janusin |
| Synonyms | J1NRM, J1-tenascin, janusin, NEDSTO, restrictin, tenascin R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fibronectin III-like domain
- fibronectin-like domain
- sphingolipid binding
- fibrinogen-like domain
- FN3
- integrin binding
- Fibronectin type 3 domain
- EGF-like domain
- FReD
- Tenascin EGF domain
- cysteine rich domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-progressive neurodevelopmental disorder with spasticity and transient opisthotonus
- ischemic stroke
- acute myeloid leukemia
- hepatic fibrosis
- corneal astigmatism
- attention deficit hyperactivity disorder
- survival
role in cell
- formation
- expression in
- migration
- synaptic transmission
- formation in
- size
- development
- stabilization
- binding
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- Extracellular Space
- synaptic vesicles
- synapse
- extracellular matrix
- membrane rafts
- perikaryon
- perineuronal net
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory exploration behavior
- synapse organization
- negative regulation of synaptic transmission
- negative regulation of cell-cell adhesion
- neuron cell-cell adhesion
- axon guidance
- telencephalon cell migration
- cell adhesion
- axon extension involved in regeneration
- associative learning
- negative regulation of axon extension involved in regeneration
- positive regulation of transmission of nerve impulse
- regulation of cell differentiation
- negative regulation of neuron projection development
- extracellular matrix organization
- long-term synaptic potentiation
- regulation of cell adhesion
- positive regulation of synaptic transmission, glutamatergic
- regulation of cell migration
- neuromuscular process controlling balance
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane raft
- perineuronal net
- extracellular region
- cell surface