HOMER1 Gene Summary [Human]
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HOMER1 |
| Official Name | homer scaffold protein 1 [Source:HGNC Symbol;Acc:HGNC:17512] |
| Ensembl ID | ENSG00000152413 |
| Bio databases IDs | |
| Aliases | homer scaffold protein 1 |
| Synonyms | HOMER, HOMER1A, HOMER1B, HOMER1C, HOMER1F, homer scaffolding protein 1, homer scaffold protein 1, PSD-Zip45, SYN47, Ves-1, Vesl-1, Vesl-1l |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HOMER1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nuf2, DHR10-like domain
- Autophagy protein 16 (ATG16)
- binding protein
- G-protein-coupled receptor binding
- ion channel binding
- EVH1 domain
- protein binding
- receptor binding
- Pleckstrin homology-like domain
- structural molecule
- identical protein binding
Pathways
Biological processes and signaling networks where the HOMER1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epileptic seizure
- chronic pain
- androgenic alopecia
- Alzheimer disease
- cognitive impairment
- renal agenesis
- Duchenne muscular dystrophy
- Huntington disease
role in cell
- accumulation in
- expression in
- apoptosis
- phosphorylation in
- quantity
- synaptic transmission
- coupling in
- ocular dominance index
- cross-sectional area
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- apical compartment
- postsynaptic region
- cellular membrane
- Endoplasmic Reticulum
- costameres
- cytosol
- dendritic spines
- synaptic vesicles
- neurites
- synapse
- Z line
- perikaryon
- axons
- dendrites
- postsynaptic density
- excitatory synapses
- dendritic shafts
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HOMER1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of calcium ion import
- positive regulation of calcium ion transport
- synaptic transmission
- response to nicotine
- positive regulation of signal transduction
- circadian rhythm
- G-protein coupled glutamate receptor signaling pathway
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
- behavioral response to cocaine
- skeletal muscle contraction
- skeletal muscle fiber development
- protein tetramerization
- response to calcium ion
- protein localization to synapse
- regulation of synaptic transmission, glutamatergic
- regulation of store-operated calcium entry
- regulation of cation channel activity
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- neuron spine
- excitatory synapse
- costamere
- neuronal cell body
- plasma membrane
- Z disc
- dendrite
- apical part of cell
- cytoplasm
- dendritic shaft
- dendritic spine
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- type 5 metabotropic glutamate receptor binding
- scaffold protein binding
- G-protein coupled glutamate receptor binding
- protein binding
- signaling adaptor activity
- ion channel binding